This medication will trigger constipation. If you do not Have got a bowel movement for 3 days, simply call your treatment group.
Get professional medical assistance right away when you detect any of the following: sluggish/shallow breathing, intense drowsiness/difficulty waking up, confusion.
Epinephrine – Due to prospective for promethazine to reverse epinephrine's vasopressor influence, epinephrine shouldn't be utilised to treat hypotension connected with promethazine overdose.
The consequences of concomitant use or discontinuation of cytochrome P450 3A4 inducers, 3A4 inhibitors, or 2D6 inhibitors with codeine are intricate.
Dextromethorphan is accessible in both equally prescription and nonprescription items. Examine the labels of your medications to ensure you are certainly not getting more than one products that contains dextromethorphan.
The combination of promethazine hydrochloride and codeine phosphate is contraindicated in pediatric clients less than six years of age. Concomitant administration of promethazine products with other respiratory depressants has an Affiliation with respiratory despair, and in some cases Loss of life, in pediatric sufferers. The Affiliation does indirectly relate to individualized pounds-dependent dosing, which could usually allow Risk-free administration.
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Promethazine HCl and Codeine Phosphate Oral Remedy needs to be utilized with caution in patients with bone- marrow depression. Leukopenia and agranulocytosis have been reported, generally when promethazine has become Employed in Affiliation with other regarded marrow-poisonous agents.
The estimated track record danger of major delivery defects and miscarriage for the indicated population is unidentified. All pregnancies have a qualifications hazard of delivery defect, decline, or other adverse results.
Instruct nursing mothers to talk to the infant's medical doctor immediately whenever they see these indications and, if they can not reach the medical doctor right away, to go ahead and take baby to an crisis area or simply call 911 (or neighborhood emergency products and services).
However, this influence just isn't consistent and may be offset by a heightened price of cervical dilation, which tends to shorten labor. Monitor neonates subjected to opioids throughout labor for signs of excess sedation and respiratory despair.
Codeine is thought being significantly excreted through the kidney, and the chance of adverse reactions to this drug may be greater in patients with impaired renal function.
It is critical which you recognize the rules with the Opioid Analgesic REMS method to circumvent addiction, abuse, and misuse of codeine. This medication must also include a Medication Guidebook. Go through and follow these Recommendations carefully. Browse it all over again every time you refill your prescription in case You can find new info. Inquire your physician For those who have any inquiries.